By Roberta Attanasio A few decades ago, the hypothesis of the Developmental Origins of Health and Disease (DOHaD), also called “Barker’s hypothesis,” stimulated interest in the fetal origins of adult disorders—as soon as it was formulated. Subsequent research by Mohan Manikkam and Michael Skinner helped establish the principle of transgenerational toxicity by showing that the effects of toxic chemicals can extend even to the third generation of offspring. Indeed, it is now clear that early life development is a critical and unique window of vulnerability during which environmental exposures influence cellular programming in ways that shape health and disease later in life. While most research on the transgenerational effects of…